Checking the Brain’s Immune Privilege: Evolving Theories of Brain–Immune Interactions
نویسندگان
چکیده
منابع مشابه
Immune Privilege
T he concept of immune privilege refers to the observation that tissue grafts placed in certain anatomical sites, including the brain and eye, can survive for extended periods of time (1). Immune privilege is thought to reflect an evolutionary adaptation to protect vital structures from damage by inflammatory responses directed against pathogens. It was originally believed that antigens in immu...
متن کاملMechanism of Immune Privilege
The eye is a privileged site that cannot tolerate destructive inflammatory responses. Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage. In contrast, viral infection in gid mice, which lack functional FasL, resulted in an inflammation and invasion of ocul...
متن کاملThe testis in immune privilege.
The production, differentiation, and presence of male gametes represent inimitable challenges to the immune system, as they are unique to the body and appear long after the maturation of the immune system and formation of systemic self-tolerance. Known to protect germ cells and foreign tissue grafts from autoimmune attack, the 'immune privilege' of the testis was originally, and somewhat simpli...
متن کاملOcular immune privilege
The eye attempts to limit local immune and inflammatory responses to preserve vision. This phenomenon, known as ocular immune privilege, is mediated by a combination of local and systemic mechanisms. While immune privilege is believed to protect the eye from day-to-day inflammatory insults, it is not absolute and its mechanisms are still incompletely understood.
متن کاملThe Immune Privilege of the Testis
Male germ cells (GC) enter meiosis beginning their complex transition into highly specialized spermatozoa at the time of puberty, after the establishment of immune competence. During the process, a myriad of surface and intracellular proteins are expressed, yet these new autoantigens are tolerated by the testis. The immunogenicity of the proteins is not diminished, as shown by their ability to ...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2017
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2016.10.027